Our recent activity is a good mixture of basic and applied research in polymer science. The challenges of the modern world, changing very rapidly, shift the point of gravity of our activity more in the direction of applied research, mostly in the area of bio-medical applications of polymeric materials. We are naturally supported by our location among other institutes of Polish Academy of Sciences with biological profiles, being our natural partners for scientific cooperation. Basing on our fundamental knowledge in the area of polymer physics, materials science, chemistry and biotechnology we are entering deeper and deeper into rapidly growing field of tissue engineering. Great part of our activity is related to polymeric biodegradable scaffolds for tissue regeneration as well as materials for drug release. Being open for various methods of scaffolds formation, at the moment we are concentrated on the formation of scaffolds by electrospinning, cooperating from the very beginning with Prof. Tomasz Kowalewski from our Institute, who is a pioneer in the field of electrospinning not only in our Institute but most probably in Poland. The main advantage of electrospinning as a method of scaffold formation is that it allows formation of nonwovens containing nano- and submicron- fibers with the morphology mimicking the natural extracellular matrix (ECM). The morphology of electrospun materials is highly sensitive to the electrospinning conditions. We are interested in investigations of the effect of electrospinning conditions on a morphology/structure of resulting fibers and nonwovens, having in a perspective more practical aim - optimization of materials for tissue engineering applications. Determination of the general relationship “formation conditions-structure-properties” for particular material system enables further optimization of electrospinning of particular polymeric materials from the perspective of cellular response. This type of analysis we apply for various biodegradable polymers, both synthetic and/or biopolymers, as candidates for scaffolds applicable for various type of tissues with some specific requirements. Additionally we perform electrospinning using different types of solvents, trying to develop the method which is as green as possible. This point is important not only for an operator but also for the cells being further cultivated onto scaffolds. The next point of our activity is related to the investigations of drugs delivery from nano- and sub-micron fibers. Coming to the most applicable part of our activity, we can mention our efforts toward formation of some medical products from biodegradable polymers, for instance expandable biodegradable external support device designed to mitigate causative factors for early and late graft failure.